G-Protein Function Is Reduced in Hypertension

G-protein function is reduced in hypertension.

A functional impairment in vasodilator tone may be important in the pathogenesis and/or maintenance of elevated peripheral vascular resistance in hypertension. Previous studies of hypertensive subjects have demonstrated impaired beta-adrenergic-mediated vasodilation paralleling a reduction in lymphocyte beta-adrenergic-stimulated adenylyl cyclase activity. We have suggested that this impairment...

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G-protein-coupled receptor kinase activity is increased in hypertension.

Impaired vascular beta-adrenergic responsiveness may play an important role in the development and/or maintenance of hypertension. This defect has been associated with an alteration in receptor/guanine nucleotide regulatory protein (G-protein) interactions. However, the locus of this defect remains unclear. G-Protein-coupled receptor kinases (GRKs) phosphorylate serine/threonine residues on G-p...

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Determination of a Matrix Function in the Form of f(A)=g(q(A)) Where g(x) Is a Transcendental Function and q(x) Is a Polynomial Function of Large Degree Using the Minimal Polynomial

Matrix functions are used in many areas of linear algebra and arise in numerical applications in science and engineering. In this paper, we introduce an effective approach for determining matrix function f(A)=g(q(A)) of a square matrix A, where q is a polynomial function from a degree of m and also function g can be a transcendental function. Computing a matrix function f(A) will be time- consu...

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Hypertension and reduced renal function: a rebuttal

First of all, compliments for the new and wider “dress and mission” of the journal of our society. As it is destined for a double audience, it is no surprise that each paper will naturally be seen from two different points of view. Even though many of the Italian emergency physicians (EP), at the beginning of Italian speciality courses in emergency medicine (EM), started out in Internal Medicin...

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More on hypertension and reduced renal function

First of all, compliments for the new and wider “dress and mission” of the journal of our society. As it is destined for a double audience, it is no surprise that each paper will naturally be seen from two different points of view. Even though many of the Italian emergency physicians (EP), at the beginning of Italian speciality courses in emergency medicine (EM), started out in Internal Medicin...

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G-Protein Function Is Reduced in Hypertension

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